The basophil activation test reflects the severity and the threshold of allergic reactions to peanut – a double-blind-placebo-controlled peanut challenge study
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چکیده
Results 44 peanut allergic children (median age 5 years) reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein. The mean %CD63+ basophil at 10 and 100 ng/ml of PE was independently associated with severity (p=0.012) whilst CD-sens (1/EC50x100) was independently associated with threshold (p=0.039) of allergic reactions to peanut. Severity and threshold parameters were correlated both at the clinical (Rs=-0.38; p=0.013) and at the basophil level (Rs=0.65; p<0.001).
منابع مشابه
Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut
BACKGROUND The management of peanut allergy relies on allergen avoidance and epinephrine autoinjector for rescue treatment in patients at risk of anaphylaxis. Biomarkers of severity and threshold of allergic reactions to peanut could significantly improve the care for patients with peanut allergy. OBJECTIVE We sought to assess the utility of the basophil activation test (BAT) to predict the s...
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